The Ohio Lottery offers multiple draw games for those aiming to win big. Here’s a look at May 21, 2025, results for each game: Powerball drawings are held Monday, Wednesday and Saturday at 10:59 p.m.

CLEVELAND, Ohio — Mega Millions will kick off the weekend’s lottery drawings with a jackpot estimated at $154 million for Friday, May 23, 2025. The Saturday, May 24 Powerball jackpot is an estimated $163 million while the Classic Lotto jackpot is $3 million.

COLUMBUS, Ohio — Although no one won the $147 million Powerball jackpot in the latest drawing on Wednesday evening, many players in Ohio took home a bit more cash. The winning numbers for Powerball on May 21 were 9, 29, 31, 34 and 43 The Powerball was 2 and the Power Play was 2x.