At least 12 fatalities have been reported in Missouri, according to the Missouri State Emergency Management Agency. The deaths come as a massive storm system moving across the country unleashed winds that damaged buildings, whipped up deadly dust storms and fanned more than 100 wildfires.

A cross-country storm will explode in strength as it moves over the central United States Friday, delivering extreme weather to millions through the weekend, including the chance of multiple strong tornadoes.

A sprawling storm system crossing the U.S. on Friday overturned semitrucks on highways and fanned wildfires in Texas and Oklahoma, where officials called for evacuations in at least one town. Tornado threats loomed for the Mississippi Valley into the night and the Deep South on Saturday.

A dangerous tornado outbreak featuring the potential for "multiple violent" tornadoes threatens much of the Deep South Saturday, as the second day of deadly severe weather continues across the eastern U.

Hundreds of homes were destroyed as wildfires swept across Oklahoma, prompting authorities to issue evacuation orders.