Schwimmer, who has also appeared in Six Days Seven Nights, Band of Brothers and voiced Melman in Madagascar, noted joining Goosebumps: The Vanishing was “an opportunity to challenge” himself “and to grow as an actor and try something new.”

David Schwimmer recalled Matt LeBlanc's "genuinely frightening" on-set injury that led to the actor being hospitalized. The two co-starred in "Friends" for 10 seasons.