Optogenetic tools enable very precise spatiotemporal control of the signaling pathway. The authors developed an optimized light-regulated PKC epsilon, Opto-PKCepsilon using AlphaFold for rational ...
(a) Schematic of the ideal properties of an optically-controlled PKCÉ›. Small molecule activators possess off-target effects, without spatiotemporal specificity. Direct optogenetic control of PKCÉ› ...
Psoriatic arthritis (PsA) is a heterogeneous, chronic inflammatory musculoskeletal disease associated with psoriasis, a chronic autoimmune skin disease affecting 2-3% of the world’s population and ...
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