SAN ANTONIO – Before Duke coach Jon Scheyer coached in his first official game after taking over for Mike Krzyzewski two seasons ago, he flew his team to Houston to play in a secret preseason scrimmage. Scheyer intentionally sought out Kelvin Sampson and the Cougars for his first career "game."

What are Final Four odds now? What to know about Houston Cougars vs Duke Blue Devils point spread, moneyline, over/under for March Madness betting.

The transfer portal played a major role in the shaping of this year's Final Four, but it's far from the only factor.

The four teams participating in the Final Four this weekend in San Antonio are a perfect microcosm of the new era in college basketball. While a team such as Duke has built its roster with former blue-chip recruits such as Cooper Flagg,

There are plenty of fun bets relating to the Final Four, from how many dunks Houston will have to which team will get to 15 points first.

Take a look at the site's Final Four picks for the NCAA Tournament semifinal matchups, which start with the Florida Gators vs Auburn Tigers and conclude with the Duke Blue Devils vs Houston Cougars.Start the day smarter.

In 2025, the crown will go to a No. 1 seed, as all four top dogs — Auburn, Duke, Florida and Houston — advanced to the Final Four for the second time in tournament history. The Blue Devils face the Cougars, while the Tigers take on the Gators, both in San Antonio on April 5.

NCAA Tournament Final Four matchup between the Duke Blue Devils and Houston Cougars with predictions, odds, picks, spread, betting lines and more.

The Duke Blue Devils face the Houston Cougars in the Final Four of the men’s NCAA Tournament at the Alamodome in San Antonio, Texas, on Saturday, April 5, 2025.